Inhibition of nucleocytoplasmic transport by vesicular stomatitis virus M protein-like polypeptides

摘要

A fragment of vesicular stomatitis virus (VSV) matrix protein (M protein) and M proteins of other viral species that can inhibit nucleocytoplasmic transport of RNA, proteins and RNA-protein complexes are disclosed. These polypeptide products and related polypeptides can be used to inhibit nucleocytoplasmic transport. Further disclosed are fragments of the VSV M protein that can enter into the nucleus of a cell. These fragments and the full length of the VSV M protein can be used to introduce other polypeptides into the nucleus of a cell.