发明名称 |
SPIRO-HYDANTOIN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS |
摘要 |
Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates,enantiomers, and diastereomers, and prodrugs thereof, (I) are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2 ,R4a, R4b, and R4c are as defined in the specification.
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申请公布号 |
WO03029245(A1) |
申请公布日期 |
2003.04.10 |
申请号 |
WO2002US31283 |
申请日期 |
2002.09.30 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;CEREP SA;DHAR, T. G. MURALI;POTIN, DOMINIQUE;MAILLET, MAGAILI JEANNINE BLANDINE;LAUNAY, MICHELE;NICOLAI, ERIC ANTOINE;IWANOWICZ, EDWIN J. |
发明人 |
DHAR, T. G. MURALI;POTIN, DOMINIQUE;MAILLET, MAGAILI JEANNINE BLANDINE;LAUNAY, MICHELE;NICOLAI, ERIC ANTOINE;IWANOWICZ, EDWIN J. |
分类号 |
C07D233/76;A61K31/4166;A61K31/4184;A61K31/4188;A61K31/4192;A61K31/4196;A61K31/42;A61K31/427;A61K31/428;A61K31/4439;A61K31/454;A61K31/4545;A61K31/4709;A61K31/497;A61K31/498;A61K31/501;A61K31/506;A61K31/5377;A61K31/541;A61P1/00;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P7/00;A61P9/00;A61P9/10;A61P11/00;A61P11/08;A61P13/12;A61P17/00;A61P17/06;A61P19/02;A61P19/10;A61P25/00;A61P25/28;A61P27/02;A61P27/16;A61P29/00;A61P37/02;A61P37/06;A61P37/08;A61P39/02;C07D233/96;C07D235/02;C07D401/04;C07D401/14;C07D487/10;C07D487/20;C07D519/00;(IPC1-7):C07D401/04;A61K31/416 |
主分类号 |
C07D233/76 |
代理机构 |
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