| 摘要 |
Disclosed are novel compounds of the Formula I that are A3 adenosine receptor agonists, useful for treating various disease states, including cancer, cardiac ischemia, leukopenia, and neutropennia. Formula (I) wherein: R<1> is optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; X is a covalent bond or optionally substituted alkylene; R<1> is R<4> Z-Y-C=C- or optionally substituted pyrazolyl: in which Y is optionally substituted alkylene, Z is oxygen, sulfur or NH-, and R<4> is optionally substituted aryl or optionally substituted heteroaryl; and R<3> is hydroxymethyl or C(0)-NR<5>R<6>; in which R<5> and R<6> are independently hydrogen or lower alkyl. |
