发明名称 |
Transporters comprising spaced arginine moieties |
摘要 |
The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit "Z" is L-arginine or D-arginine, and subunit "Y" is an amino acid that does not comprise an amidino or guanidino moiety. Subscript "n" is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.
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申请公布号 |
US2003032593(A1) |
申请公布日期 |
2003.02.13 |
申请号 |
US20020078247 |
申请日期 |
2002.02.14 |
申请人 |
CELLGATE, INC. |
发明人 |
WENDER PAUL A.;ROTHBARD JONATHAN B.;WRIGHT LEE;KREIDER ERIK L.;VANDEUSEN CHRISTOPHER J. |
分类号 |
A61K31/522;A61K38/00;A61K47/48;A61P31/12;A61P35/00;A61P43/00;C07K7/06;C07K7/08;C07K14/00;(IPC1-7):A61K38/16;C12N15/85 |
主分类号 |
A61K31/522 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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