摘要 |
The present invention provides nucleic acids encoding B7-related factors tha t modulate the activation of immune or inflammatory response cells, such as T- cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL2 and splice variants thereof. The present invention further provides isolated B7-related polypeptides that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizi ng B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for diagnostic applications and the immunomodulation of a human o r animal subject. |