A method and system of operating dynamic element matching ("DEM") system with two or more power supplies are disclosed. A connection system (12) of the DEM system is driven with one power supply operating at one voltage. Connection system couples to components that are to be matched and equalized in usage by ordering outputs to components and activating the components according to ordered outputs. A connection calculator (16) of the DEM system is driven with another power supply operating at another voltage different from the one voltage. Connection calculator is coupled to the connection system, and connection calculator calculates an order of usage of components. A level shifter system (14) level shifts voltage levels of signals from connection system to connection calculator, and another level shifter system (18) level shifts voltage levels of signals from connection calculator to connection system.
