VERFAHREN ZUR DIAGNOSE ODER ZUR PROGNOSE VON ALZHEIMER KRANKHEIT: THERAPEUTISCHE ZUSAMMENSETZUNG ZUR VERHINDERUNG ODER ZUR BEHANDLUNG VON ALZHEIMER KRANKHEIT

摘要

The invention relates to a method of predicting an increased risk of a patient having Alzheimer's disease (AD) or for a subject of developing AD comprising : a) assaying a DNA-containing biological sample for the allele of the APOE gene ; b) assaying the plasmatic level of protein Lp(a) or glycoprotein Apo(a), wherein the presence of an epsilon 4 allele of the APOE gene and an increased plasmatic level of Lp(a)­/Apo(a) indicates an increased risk for the patient having Alzheimer's disease or developing AD. The invention further provides a therapy for preventing or treating AD consisting of decreasing the plasmatic level of Lp(a) or the interaction of Lp(a) with its receptor in a patient bearing at least one APOE epsilon 4 allele.