POLYION COMPLEX MICELLES OF CORE/SHELL STRUCTURE

摘要

Disclosed is a stabilizing method for polyion complex micelles having a core-shell structure which is formed from a block copolymer comprising a hydrophilic segment and a chargeable segment and a polyelectrolyte. Such stabilizing method can be achieved by endowing the chargeable segment in the block copolymer forming a core part with at least one thiol residue and allowing cross-links of disulfide bonds via the thiol residues endowed to them to be formed between the above chargeable segments. The representative of the copolymer which can be prepared by such stabilizing method can be represented by Formula (I), (II) or (III). Thus, capable of being provided is the stabilizing method for polyion complex micelles which can be utilized as a carrier for a polyelectrolyte. <CHEM> <CHEM> <CHEM>