发明名称 |
MUTANTS OF STREPTOCOCCAL TOXIN A AND METHODS OF USE |
摘要 |
This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.
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申请公布号 |
US2002086813(A1) |
申请公布日期 |
2002.07.04 |
申请号 |
US19990308830 |
申请日期 |
1999.08.04 |
申请人 |
REGENTS OF THE UNIVERSITY OF MINNESOTA |
发明人 |
SCHLIEVERT PATRICK M.;ROGGIANI MANUELA;AUGE JENNIFER STOEHR;OHLENDORF DOUGLAS |
分类号 |
C12N15/09;A61K38/00;A61K39/00;A61K39/09;A61P31/04;C07K14/315;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/31;(IPC1-7):A01N37/18;A61K31/58 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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