发明名称 |
Methods for treating pain by administering peptides derived from human basic proline-rich lacrimal protein |
摘要 |
The invention relates to an in vitro method for prognosis, diagnosis or determination of the evolution of a condition involving an altered production of Basic Proline-rich Lacrimal Protein (BPLP) or of any of its maturation products, by detecting, or quantifying in a biological sample of a test subject, a BPLP protein or a maturation product thereof, and comparing the production of BPLP protein or maturation product with the production of the same in a biological sample of a control subject. |
申请公布号 |
US9403871(B2) |
申请公布日期 |
2016.08.02 |
申请号 |
US201414281018 |
申请日期 |
2014.05.19 |
申请人 |
INSTITUT PASTEUR |
发明人 |
Rougeot Catherine;Huaulme Jean-Francois;Ungeheuer Marie-Noelle;Wisner Anne;Dufour Evelyne |
分类号 |
A61K38/03;C07K7/06;C07K5/083;C07K5/113;C07K7/08;C07K14/47;C07K14/81;C07K16/18;G01N33/68;A61K38/00 |
主分类号 |
A61K38/03 |
代理机构 |
Law Office of Salvatore Arrigo and Scott Lee, LLP |
代理人 |
Law Office of Salvatore Arrigo and Scott Lee, LLP |
主权项 |
1. A method for treating pain comprising administering an effective amount of an isolated peptide consisting of up to 15 amino acids to a human subject,
wherein the peptide comprises the sequence Glu-Arg-Phe-Ser-Arg (SEQ ID NO: 3) or Glp-Arg-Phe-Ser-Arg (SEQ ID NO: 7), wherein the peptide exhibits an inhibitory property against a neutral endopeptidase or an aminopeptidase and wherein the peptide has the same amino acid sequence as that found within human Basic Proline-rich Lacrimal Protein (SEQ ID NO:2) or differs from the amino acid sequence found within SEQ ID NO:2 by two or less amino acid substitutions. |
地址 |
Paris FR |