发明名称 |
Medicament for prevention of nephrotoxicity or renal dysfunction or decrease in development thereof and pharmaceutical preparation |
摘要 |
<p>A method of preventing, reducing or reversing nephrotoxicity or renal dysfunction induced by administration of a cyclosporin or tacrolimus to a mammalian patient. The method comprises the co-administration to the patient, either before, together with or after cyclosporin or tacrolimus administration, of a pharmaceutical composition containing an effective amount of pentosan polysulfate (PPS) or a pharmaceutically acceptable salt thereof. The oral route of administration is preferred. The total daily dosage of PPS or PPS salt ranges from about 2 to about 50 mg/kg of patient body weight, or about 140 to about 3,500 mg per day in adult human patients. Also disclosed are a method of providing immunosuppressive therapy to a patient while avoiding cyclosporin or tacrolimus-induced nephrotoxicity, and combination pharmaceutical compositions to be used in such therapy.</p> |
申请公布号 |
CZ20001274(A3) |
申请公布日期 |
2001.12.12 |
申请号 |
CZ20000001274 |
申请日期 |
1998.10.09 |
申请人 |
BAKER NORTON PHARMACEUTICALS, INC.;THE UNITED STATES OF AMERICA, REPRESENTED BY THE S |
发明人 |
STRIKER GARY E.;STRIKER LILLIANE;KORTRIGHT KENNETH H. |
分类号 |
A61K38/00;A61K31/436;A61K31/70;A61K31/715;A61K31/737;A61K38/08;A61K38/13;A61K45/06;A61P13/12;A61P37/06;A61P39/00;(IPC1-7):A61K31/737 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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