| 摘要 |
<p>MCM3AP (mini chromosome maintenance 3 associated protein) is characterised herein as a nuclear localised acetyltransferase which acetylates both the chromatin-associated protein MCM3 (mini chromosome maintenance 3) and histone H3. The acetyltransferase activity is shown to repress DNA replication. Methods, uses and assays for obtaining agents useful in the modulation of cellular proliferation are provided.</p> |
