| 摘要 |
Mometasone (9 alpha ,21-dichloro-1 beta ,17 alpha -dihydroxy-16 alpha -methyl-pregna-1,4-dine-3,20-dione) is prepared from icomethasone (9 alpha -chloro-11 beta ,17 alpha ,21-trihydroxy-16 alpha -methyl-pregna-1,4-diene-3,20-dione) by reaction thereof with a sulfonyl chloride of formula R-C1O2S wherein R is CH3 or p-CH3C6H4 in the presence of a tertiary amine and solvent, and the 21-sulfonate so obtained is reacted with a source of chloride ions. The new compound mometasone thus obtained is a potent anti-inflammatory agent. |
