THE PARENTERAL USE OF BACTERIAL PHAGE ASSOCIATED LYSING ENZYMES FOR THE THERAPEUTIC TREATMENT OF BACTERIAL INFECTIONS

摘要

The present invention discloses a method and composition for the treatment o f bacterial infections by the parenteral introduction of a therapeutic agent comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein th e lytic enzyme is selected from the group consisting of lytic enzymes, and modified lytic enzymes such as shuffled lytic enzymes, chimeric lytic enzyme s, and combinations thereof, wherein said lytic enzyme is in an appropriate carrier for delivering the lytic enzyme into a patient. The therapeutic agen t may additionally include a holin enzyme, which may be a shuffled holin enzym e or a chimeric holin enzyme. The injection can be done intramuscularly, subcutaneously, or intravenously.