| 发明名称 |
Pyrrolidine derivatives as cyclic amp-specific phosphodiesterase inhibitors |
| 摘要 |
Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed. |
| 申请公布号 |
AU2426201(A) |
申请公布日期 |
2001.07.09 |
| 申请号 |
AU20010024262 |
申请日期 |
2000.11.28 |
| 申请人 |
ICOS CORPORATION |
发明人 |
TIMOTHY J. MARTINS;KERRY W. FOWLER;JOSHUA ODINGO;EDWARD A. KESICKI;AMY OLIVER;LAURENCE E BURGESS;JOHN J GAUDINO;ZACHARY S. JONES;BRADLEY J. NEWHOUSE;STEPHEN SCHLACHTER |
| 分类号 |
A61K31/40;A61K31/4025;A61K31/4184;A61K31/4245;A61K31/427;A61K31/4439;A61K31/506;A61P1/00;A61P1/04;A61P3/04;A61P3/10;A61P9/00;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P11/08;A61P13/12;A61P15/00;A61P15/10;A61P17/00;A61P17/06;A61P19/02;A61P19/08;A61P19/10;A61P25/00;A61P25/14;A61P25/16;A61P25/22;A61P25/24;A61P27/02;A61P29/00;A61P31/04;A61P33/06;A61P35/02;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07D207/08;C07D207/12;C07D295/14;C07D295/18;C07D295/20;C07D401/04;C07D401/06;C07D401/12;C07D403/04;C07D403/12;C07D405/06;C07D405/12;C07D407/12;C07D409/12;C07D413/12;C07D417/06;C07D417/12 |
主分类号 |
A61K31/40 |
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