Attachment of acid moiety-containing biomolecules to activated polymeric surfaces

摘要

Compositions comprising an activated polymeric substrate having an acid moiety-containing biomolecule covalently bonded via the acid moiety to the substrate are disclosed. Methods for making such compositions are also provided, including methods that involve plasma processing of the substrate prior to the attachment of the biomolecule. These compositions find use as novel biomaterials, e.g. for tissue engineering and the prevention of adhesions, for selective attachment and growth of specific cell types, for coating surgically-implanted materials, and in coating vessels for storage of blood and blood products.