| 摘要 |
PROBLEM TO BE SOLVED: To obtain a preventive or therapeutic agent of rheumatism, having excellent activities as the preventive or therapeutic agent of the rheumatism such as inflammatory rheumatism, and providing small toxicity by including a specific sulfonamide derivative (salt) as an active ingredient. SOLUTION: The objective preventive or therapeutic agent contains a sulfonamide derivative (salt) of the formula [R1 is H, a halogen, a lower alkyl, nitro, OH or the like; R2 and R3 are each H, a halogen, a lower alkyl or a lower alkoxy; A is =N-or =CH-; B is a (substituted) aromatic six-membered ring (including one to two Ns) in the ring or CO-R4 (R4 is H, a lower alkyl, 2-thienyl or the like)] as an active ingredient. The derivative is exemplified by N- 2-[(4- hydroxyphenyl)amino]-3-pyridyl}-4-methoxybenzenesulfonamide. The preventive or therapeutic agent is orally or parenterally (whole body administration, topical administration or the like) administered.
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