| 摘要 |
A fibrinogen-free, factor XIII preparation is stabilized with a di- or tricarboxylic acid salt and other stabilizers. Also new are fibrinogen-containing preparations stabilized with chaotropic substances and a tissue adhesive pack consisting of the factor XIII preparation, a fibrinogen-containing preparation and a thrombin preparation. A stabilized, fibrinogen-free, protein preparation which can be stored in liquid form contains: (a) blood coagulation factor XIII; (b) a di- or tricarboxylic acid salt, especially a citrate; and (c) additional factor XIII stabilizers. Independent claims are also included for: (A) a stabilized, liquid or deep-frozen protein preparation containing fibrinogen and less than 0.28 mol/l of a chaotropic substance which prevents or reduces fibrinogen aggregation; and (B) a tissue adhesive comprising a unit pack containing as separate components either: (i) the stabilized fibrinogen-free protein preparation, the stabilized, liquid or deep-frozen, fibrinogen-containing protein preparation and a thrombin-containing preparation; or (ii) a mixture of the fibrinogen-free and fibrinogen-containing protein preparations and a thrombin-containing preparation. |
