发明名称 |
Synthetic peptides for the treatment of myasthenia gravis |
摘要 |
Peptides having at least nine amino acid residues each including an amino acid sequence which corresponds to position p200-208 or p262-266 of the human acetylcholine receptor alpha -subunit, but differing therefrom by one or more amino acid substitutions, are disclosed. These peptides inhibit the proliferative response of human peripheral blood lymphocytes to the myasthenogenic peptides p195-212 and p259-271 and are suitable for treatment of subjects afflicted with myasthenia gravis.
|
申请公布号 |
US6066621(A) |
申请公布日期 |
2000.05.23 |
申请号 |
US19950475577 |
申请日期 |
1995.06.07 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
SELA, MICHAEL;MOZES, EDNA |
分类号 |
A61K38/00;A61K39/00;A61P43/00;C07K14/705;G01N33/564;G01N33/569;(IPC1-7):A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|