| 摘要 |
<p>The present invention relates to therapeutically active bicyclic compounds, processes for the manufacture of said compounds, pharmaceutical formulations containing said compounds and the use of said compounds in the treatment and prophylaxis of viral infections, more particularly infections caused by viruses which encode for a serine protease enzyme, especially viruses of the Herpes family. The invention provides compound of general formula (I) (relative stereochemistry shown) and pharmaceutically acceptable derivatives thereof, wherein R represents H substituted or unsubstituted C1-3 alkyl; R1 represents optionally substituted heteroaryl or fused heteroaryl, with one to four heteroatoms, or R9CO; R3 represents C1-6alkyl, C1-6alkenyl, optionally substituted three to seven member, preferably four to seven member, N-heterocycle containing up to two heteroatoms, (a) or (b); and R4, R5, R6, R7 and R9 independently represent H or a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or heteroaryl group as defined in the specification.</p> |
