Inhibitor of brn-3b and its use for the treatment of breast and ovarian cancer

摘要

An inhibitor of Brn-3b expression and/or activity is useful in the treatment of breast or ovarian cancer. A method for identifying an inhibitor of Brn-3b expression comprises: (a) providing a test construct comprising a Brn-3b promoter operably linked to a coding sequence; (b) contacting a substance to be tested with the test construct under conditions that would permit the polypeptide encoded by the said coding sequence to be expressed in the absence of the said substance; and (c) determining whether the said substance inhibits the expression of Brn-3b.