发明名称 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
摘要 |
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable conjugate. The targetable conjugate comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable conjugate further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them. |
申请公布号 |
AU4579299(A) |
申请公布日期 |
2000.01.10 |
申请号 |
AU19990045792 |
申请日期 |
1999.06.22 |
申请人 |
IMMUNOMEDICS INC. |
发明人 |
HANS J. HANSEN;GARY L. GRIFFITHS;SHUI-ON LEUNG;WILLIAM J. MCBRIDE;ZHENGXING QU |
分类号 |
A61K33/22;A61K39/395;A61K45/00;A61K47/48;A61K49/00;A61K51/00;A61K51/08;A61K51/10;A61P35/00;A61P43/00;C07K16/18;C07K16/30;C07K16/42;C07K16/44;C07K16/46 |
主分类号 |
A61K33/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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