| 摘要 |
The present invention relates to the use of a solution comprising a non-infectious DNA molecule able to express in a mammal, a physiologically active protein, for the manufacture of a medicament intended to be delivered mainly to the mammalian skin using a needle-free apparatus adapted to this effect. The physiologically active protein can be an antigen that is (i) specific for a microorganism able to induce an infection in a mammal or (ii) tumor-associated; in this case the medicament is for treating or preventing an infection or a tumor disorder. The protein can also be a mammalian protein able to treat a genetic defect e.g., factor XIII or IX; or a cytokine. |
