发明名称 |
HUMANIZED IMMUNOGLOBULIN REACTIVE WITH -g(a)4-g(b)7 INTEGRIN |
摘要 |
<p>The present invention relates to humanized immunoglobulins having binding specificity for ±4²7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a portion of an immunoglobulin of human origin (e.g., a human framework region, a human constant region). In one embodiment, the humanized immunoglobulin can compete with murine Act-1 for binding to human ±4²7 integrin. In a preferred embodiment, the antigen binding region of the humanized immunoglobulin comprises each of the complementarity determining regions of the light and heavy chains of the murine Act-1 antibody. The present invention further relates to a humanized immunoglobulin light chain or heavy chain, isolated nucleic acids comprising a sequence which encodes a humanized immunoglobulin or immunoglobulin chain of the present invention (e.g., a single chain antibody), constructs comprising a nucleic acid of the present invention, and host cells comprising a nucleic acid of the present invention useful in a method of preparing a humanized immunoglobulin. The humanized immunoglobulins can be used in diagnostic and therapeutic applications in humans, for example to control lymphocyte infiltration (including recruitment and/or accumulation) to mucosal tissue.</p> |
申请公布号 |
EP0918797(A2) |
申请公布日期 |
1999.06.02 |
申请号 |
EP19970937148 |
申请日期 |
1997.08.06 |
申请人 |
LEUKOSITE, INC. |
发明人 |
PONATH, PAUL, D.;RINGLER, DOUGLAS, J.;JONES, S., TARRAN;NEWMAN, WALTER;SALDANHA, JOSE;BENDIG, MARY, M. |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P1/00;A61P29/00;A61P37/00;C07K14/705;C07K16/28;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/08;G01N33/531;(IPC1-7):C07K16/28 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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