Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors

摘要

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula <IMAGE> wherein each T is a substituent g roup; x is 0, 1, or 2; the group D represents <IMAGE> the subscript "e" is 2 or 3; the group R14 represents a variety of possible substituent groups of the cycloalkyl ring between D and G; the subscript "k" is 0-2; and the group G represents M, <IMAGE> in which M represents -CO2H, -CON(R11)2, or -CO2R12; and R13 represents any of the side chains of the 19 noncyclic occurring amino acids.