| 摘要 |
Compound, compositions containing compounds, methods of using compounds, and processes of making compounds, of formula (I) containing at least one ring nitrogen, or a pharmaceutically acceptable base or acid addition salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer or mixtures thereof, wherein: X is double-bonded oxygen, or -OH; when R<7> is present, it is hydrogen or lower alkyl; y represents the atoms necessary to form a fused mono-, bi- or tricyclic, carbocylic or heterocyclic ring, wherein each individual ring has 5-6 ring member atoms; and Z is (i) -CH<2>CHR<3>- wherein R<2> and R<3> are independently hydrogen, alkyl, aryl or aralkyl; (ii) -R<6>C=CR<3>- wherein R<3> and R<6> are independently hydrogen, lower alkyl, aryl, aralkyl, halo, -NO2, -COOR<7>, or -NR<7>R<8> where R<8> is independently hydrogen or C1-C9 alkyl, or R<6> and R<3>, taken together, form a fused aromatic ring, wherein each individual ring has 5-6 ring members; (iii) -R<2>C=N-; (iv) -CR<2>(OH)-NR<7>; or (v) -C(O)-NR<7>-. |
