Process for preparing glufosinate and phosphorus-containing alpha-aminonitriles as intermediates

摘要

Glufosinate and the 2-methyl analog thereof can be prepared in a multi-step synthesis from methylphosphorus compounds (II) with unsaturated keto compounds (III) via adducts (IV), subsequent reaction under the conditions of a Strecker synthesis and finally hydrolysis of the aminonitrile (V):Step 1:Step 2:Step 3: Hydrolysis of (V) to give glufosinateDepending on process conditions and substrates, various compounds can be identified as adducts (IV).