Cyclopropyl derivatives, preparation method there-of and applications

摘要

Cyclopropyl derivatives of formula (I) wherein R is cyclopropyl or methylcyclopropyl are prepared by reaction of 2,6-dibromohexanoyl chloride with 2,6-dimethylaniline in the presence of a base at 0 DEG -25 DEG C. to give 2,6-dibromohexanoyl-2,6-dimethylanilide which subsequently is reacted with R-NH2 (wherein R is cyclopropyl or methylcyclopropyl) at 70 DEG -100 DEG C. The compounds are useful as antiarrhythmic agents and as local anaesthetic agents.