| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the subject new derivative comprising an optically active specific homononactic acid derivative, having insecticidal activity and useful as a synthetic intermediate, etc., capable of stereoselectively producing homononactic acid useful as a synthetic intermediate, etc., of tetranactin. SOLUTION: This new homononactic acid derivative is represented by formula I (R<1> is a protective group of hydroxyl group) and has insecticidal activity and is useful as a synthetic intermediate of an optically active homononactic acid [(2R,3S,6R,8R)-3,6-epoxy-8-hydroxy-2-methyldecanoic acid] useful as a synthetic intermediate for tetranactin. The compound is obtained by removing an acetal-protecting group of a compound represented by formula II (Bn is benzyl), dehydrating the compound to epoxidize the compound, opening the ring of the epoxidized compound to afford a compound of formula III having allyl group, protecting hydroxyl group, cleaving the double bond to afford aldehyde, further reacting the resultant aldehyde with a phosphonic acid ester of formula IV (Et is ethyl) and subjecting the produced compound of formula V (R<2> is same as R<1> ) to iodo-etherification reaction.</p> |
