| 摘要 |
<p>gamma -Mercaptocarboxylic acids and their derivatives, in particular esters and amides, are prepared from gamma -butyrolactones via the corresponding thiolactones. The thiolactones are obtained by reaction of the lactones with thiocarboxylates in polar solvents and converted by ring opening with nucleophilic reagents such as, for example, alkali metal alkoxides into the gamma -mercaptocarboxylic acid derivatives. These are intermediates, for example for the synthesis of leukotriene antagonists.</p> |
