USE OF SUBSTITUTED (5,6)-DIHYDRONAPHTHALENYL COMPOUNDS HAVING RETINOID-LIKE ACTIVITY TO PREVENT OR REDUCE ISCHEMIC INJURY

摘要

The present invention relates to methods of preventing, or reducing the severity of, an ischemic injury originating in an animal's dermal tissue by applying to the animal a composition comprising a compound of formula (I*) or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is -O-CO-, -NH-CO-, -CS-NH-, -CO-O-, -CO-NH-, -COS-, -SCO-, -SCH2-, -CH2-CH2-, -CH=CH-, -CC-, -CH2-NH-, -COCH2-, -NHCS-, -CH2S-, -CH2O-, -OCH2-, -NHCH2- or -CR<5>=CR<6>-; n is 1 or 0; R and R are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; R<4> is -(CH2)t-Y, C1-6 alkyl, or C3-6 cycloalkyl; R<1> is -CO2Z, C1-6 alkyl, CH2OH, -CONHR, or CHO; R and R are independently hydrogen or C1-6 alkyl, or R and R together can form a radical of formula (II); Y is naphtyl or phenyl, both radicals can be optionally substituted with one to three of C1-6 alkyl or halogen, which substituents can be the same or different; Z is hydrogen or (1-6 alkyl); R<2>, R<3>, R<5>, R<6>, and R are independently hydrogen or C1-6 alkyl; and t is zero to six.