CONJUGATES PREPARED FROM METAL COMPLEXES AND OLIGOMERIC AGENTS CONTAINING SUCH CONJUGATES, THEIR APPLICATION IN RADIO DIAGNOSIS AS WELL AS PROCESS FOR PREPARING THEREOF

摘要

This invention relates to chemically modified oligonucleotide conjugates that contain a complexing agent or complex that is bound by a connecting component to the oligonucleotides. In this case, the oligonucleotides are modified in a way that prevents or at least significantly inhibits the degradation by naturally occurring nucleases. The oligonucleotide radical can bond specifically and with high bonding affinity to target structures and can thus produce a specific therapeutic or diagnostic effect by the bound complexing agent or complex.