METHOD FOR SCREENING SUBSTANCES WITH THERAPEUTIC ACTION IN THE TREATMENT OF TRANSMISSIBLE SUBACUTE SPONGIFORM ENCEPHALOPATHY

摘要

The invention concerns a method for screening substances capable of having therapeutic action in the treatment of transmissible subacute spongiform encephalopathy (TSSE) or prion diseases comprising a step of isolating the PrPres, from the spleen, methods for isolating the PrPres, particularly adapted to said screening method and their applications, in particular for detecting PrPres.