VACCINE AGAINST LYME DISEASE, PROCESS FOR OBTAINING IT, MONOCLONAL ANTIBODY, ANTIGENE, RECOMBINANT DNA, RECOMBINANT VECTOR AND PROCESS FOR OBTAINING THIS ANTIGENE

摘要

The invention refers to a passive vaccine against Lyme disease and contains one or more monoclonal antibodies, specific for 31kD antigen (OspA) and/or 34 kD antigen (OspB) B.burgdorferi. In testing animals with immunodefficiency which have been infected by vital pathogen organisms B.burgodorferi, we prevent the formation of arthritis, pancarditis and hepatitis. The invention also refers to the preparation procedure of the vaccine as described in the invention, to hybridomal cell lines ECACC 89 09 1302, ECACC 90050405, ECACC 90050406 and ECACC 90050407 which excrete antibodies referred to in the invention, and to pathogen B.burgdorferi which reacts immunologically with the antibody referred to in the invention. The invention refers also to preparation procedure of antigens and active vaccines against Lyme disease containing the antigen referred to in the invention as an important component. Finally, the invention refers to the isolation procedure and recultivation of pathogen B.burgodorferi from test animals with immunodeficiency.