Uses for DNA structure-specific recognition protein
摘要
Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.
申请公布号
US5705334(A)
申请公布日期
1998.01.06
申请号
US19940328809
申请日期
1994.10.25
申请人
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人
LIPPARD, STEPHEN J.;ESSIGMANN, JOHN M.;DONAHUE, BRIAN;TONEY, JEFFREY H.;BRUHN, SUZANNE L.;PIL, PIETER M.;BROWN, STEVEN J.;KELLETT, PATTI J.