| 摘要 |
The present invention relates to a method for the treatment of a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the blockade of chloride channels, comprising administering to a living animal body in need thereof a therapeutically effective amount of a compound having formula (I) or a pharmaceutically acceptable salt thereof wherein R<2>, R<3>, R<4> and R<5> are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or R<3> and R<4> or R<4> and R<5> together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R<2>, R<3>, R<4> and R<5> is as defined above; Y is -CO-, -CS-, -SO2-, or -C(=N-R<8>)-, wherein R<8> is hydrogen, alkyl, or cyano; X is -NH-, -CH2-NH-, -SO2-NH-, or -CH2-; Z is -NR<6>-, -O-, -CH=CH-, -N=CH-, -CH=N-, or -NR<6>-CH2-, wherein R<6> is hydrogen, or alkyl; R<11>, R<12>, R<13>, R<14> and R<15> are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or one of R<11> and R<12>, R<12> and R<13>, R<13> and R<14> or R<14> and R<15> together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R<11>, R<12>, R<13>, R<14> and R<15> is as defined above. |
