Amelioration of erectile dysfunction

摘要

Methods of treatment of erectile dysfunction are disclosed. In these methods, a medicament is introduced into the penile tissue of a patient. This medicament preferably is one which induces cavernosal smooth muscle relaxation, and/or produces an increase in the level of nitric oxide synthetase (NOS) in tissue. This treatment includes the transfer of cDNAs to the penis, wherein these cDNAs encode proteins that induce the relaxation of the corpora cavernosa smooth muscle. An isolated sequence encoding human penile inducible nitric oxide synthetase is also disclosed.