发明名称 |
ANTHRACYCLINE-CONJUGATES |
摘要 |
<p>A conjugate of formula (1), wherein the moiety A-O- is the residue of any anthracycline of formula A-O-H bearing at least one primary or secondary hydroxyl group; a is an integer of from 1 to 30; W is a residue of formula (2), wherein B represents a C1-C6 alkylene group optionally hetero interrupted and m is 0 or 1; Z is a spacer group and T is a carrier moiety. The conjugates of formula (1) of the present invention are useful antitumor agents since they contain an acetalic bond which releases the parent drug A-O-H upon hydronium-ion-catalyzed hydrolysis or ''in vivo'' enzymatic cleavage.</p> |
申请公布号 |
GR3024050(T3) |
申请公布日期 |
1997.10.31 |
申请号 |
GR19970401705T |
申请日期 |
1997.07.09 |
申请人 |
PHARMACIA & UPJOHN S.P.A. |
发明人 |
ANGELUCCI, FRANCESCO;RUGGIERI, DANIELLA;STEFANELLI, STEFANIA;SUARATO, ANTONINO;BERSANI, LAURA |
分类号 |
A61K39/395;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K47/48;A61P35/00;C07H;C07H15/252;C07K1/113;C07K14/00;C07K14/705;C07K14/715;C07K16/00;(IPC1-7):A61K47/48 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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