发明名称 |
Monoclonal antibodies cross-reactive and cross-protective against human monoclonal antibodies against pseudomonas aeruginosa serotypes |
摘要 |
Cell lines have been produced that secrete human monclonal antibodies capable of binding to the lipopolysaccharide molecules of selected Pseudomonas aeruginosa IATS serotypes. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included. Prior to filing of this patent application the continuous transformed human cell lines 1C1, 6D6, and 8H7 described herein were deposited in the American Type Culture Collection and given the designations CRL 8941, 9171, and 9258, respectively.
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申请公布号 |
US5627067(A) |
申请公布日期 |
1997.05.06 |
申请号 |
US19950462370 |
申请日期 |
1995.06.05 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
SIADAK, ANTHONY W.;ROSOK, MAE J. |
分类号 |
G01N33/569;A61K38/00;A61K39/104;C07K14/195;C07K14/41;C07K16/00;C07K16/12;C12N15/00;C12N15/02;C12P21/00;C12P21/08;C12R1/91;G01N33/577;(IPC1-7):C12N5/22;A61K39/395 |
主分类号 |
G01N33/569 |
代理机构 |
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地址 |
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