METABOLIC EFFECTS OF CERTAIN GLUTATHIONE ANALOGS

摘要

Compounds of formula (1) and the esters, amides, amide/esters and salts thereof, wherein YCO is .gamma.-glu or .beta.-asp; G* is phenylglycine or glycine; Z is CH2, O or S; and X is a hydrocarbon radical of 1-20C; are useful in modulating hematopoiesis in bone marrow, mitigating the bone-marrow-destructive effects of a chemotherapeutic agent, and in potentiating the toxicity of chemotherapeutic agents.