| 摘要 |
Cyclohexane derivs. of formula (I) and their isomers are new. R = a gp. of formula Ra-Rd; A Me and B = OR1; or A = H and B = CH2OH or CH2OR1 only when R = Rd; or A = CH2S<+>R5R6 and B = OH or OR1; or A+B with CH2O = oxirane ring; C = OH and D = H or Br; or C = OR1 and D = H or Br only when R = Rd; or C = D = H only when R = Rd; or C+D with O = oxirane ring; or C+D with OCOO = di-oxygenated heterocycle; or C+D = a bond; Y = CO or CHOR1; R1 = CONHCOR4; R2 = H or opt. substd. alkyl or aryl; R3 = H or opt. substd. alkyl or aralkyl; R4 = NH2 or opt. substd. alkyl, alkylamino, dialkylamino, aryl, aralkyl, heteroaralkyl, or alkenyl; R5 = opt. substd. alkyl; R6 = opt. substd. alkyl, aryl, aralkyl , heteroaryl or heteroaralkyl; alkyl = 1-6C; aryl = Ph or naphthyl; heteroaryl = pyridyl, quinolyl, isoquinolyl, imidazolyl, indolyl or isoindolyl; alkenyl = vinyl or isopropenyl; opt. substits. are selected from OH, halo, trihalomethyl, NO2, NH2, alkylamino, dialkylamino, 1-6C alkoxy, CO2H, 2-6C alkoxycarbonyl and 1-6C acyl. |
