| 摘要 |
PURPOSE: To obtain a new cell division mechanism control protein having a specific amino acid sequence, not manifested in stationary state and manifested in a nuclei after initiating a cell cycle and controlling cell division or differentiation of lymphocyte. CONSTITUTION: This new cell division mechanism controlling protein SPA-1 protein controls cell division or differentiation of lymphocyte and is not manifested in stationary state and manifested in a nucleus after initiating a cell cycle of lymphocyte in cell cycle of cell of mammals and has an amino acid sequence from the 1st methionine to 693th alanine or the amino acid sequence in which 1 or 2 or amino acids are added, lost or replaced in an amino acid sequence containing an amino acid sequence expressed by the formula. The protein is obtained by isolating mRNA from lymph-based cell strain, preparing cDNA library by ordinary method, screening the library with anti-SPA-1 monoclonal antibody, selecting clone containing SPA-1 gene and manifesting the gene in a host cell. |
