发明名称 |
HIGH MOLECULAR WEIGHT POLYMER-BASED PRODRUGS |
摘要 |
High molecular weight, water-soluble prodrugs of formula (I), wherein: D is a biologically active moiety; M is X or Q; X is an electron withdrawing group; Q is a moiety containing a free electron pair positioned five or six atoms from Y'; Y and Y' are oxygen or sulfur; and R is a polyalkylene oxide, are disclosed. Methods of preparing the compounds as well as methods of treatment using the compounds are also disclosed.
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申请公布号 |
CA2208841(A1) |
申请公布日期 |
1996.08.08 |
申请号 |
CA19962208841 |
申请日期 |
1996.01.30 |
申请人 |
ENZON, INC. |
发明人 |
PENDRI, ANNAPURNA;GREENWALD, RICHARD B. |
分类号 |
A61K31/335;A61K47/48;C07D305/14;C07D491/22;(IPC1-7):C07D493/04;A61K38/00;C07D405/12;A61K31/47;A61K31/77 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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