| 摘要 |
Indoline compounds represented by the general formula: <CHEM> wherein R<1> represents the group <CHEM> R<2> represents a phenyl group which may be substituted or an aromatic heterocyclic group, and R<3> represents hydrogen, a halogen, or a lower alkyl group, hydroxyl group, lower alkoxy group, carbamoyl group or lower alkoxycarbonyl group, and physiologically acceptable salts thereof, and their solvates, as well as 5-HT3 receptor antagonists containing them as effective components. The indoline compounds of the invention have stronger antagonism against intestinal 5-HT3 receptors than known 5-HT3 receptor antagonists and also have excellent sustained action, making then useful as prophylactic or therapeutic agents against vomiting or irritancy induced by chemotherapy or radiation, irritable bowel syndrome, diarrhea, and the like.
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