Carboxyalkyl heterocyclic derivatives

摘要

A compound is provided represented by the following general formula (A) wherein two of Ra, Rb and Rc are oxygen; X is a kind of benzyl, a kind of benzothiazolylmethyl, or a kind of naphthylmethyl; R is hydrogen or lower alkyl; n is an integer of 1 to 3; and Z indicates a direct bond or a bridging moiety containing one carbon atom. The compounds act as selective inhibitors of aldose reductase. The compounds provided are useful as drugs for therapy and prevention of various types of diabetic complications.