| 摘要 |
<p>3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds of general formula (I), wherein R1 is the same or different groups and represents alkyl or alkoxy groups having 1 to 3 carbon atoms, halogen, trifluoromethyl, nitro, cyano, phenyl or alkylsulphonyl groups; n is 1 to 3; X is -C(O)NH-; -SO¿2?-; -C(O)- or a direct bond; Y means -S-Z; -SO-Z; -S?+(Z)¿2, A?-; N+(Z)¿3, A-; -C(Z) = CZ¿2?; -C C-Z or a group (a), wherein b = c = N or C-Z; d = N-Z, O or S, and A?-¿ is any pharmaceutically acceptable anion; and Z is the same or different groups and represents H, cyano, nitro, trifluoromethyl, -CH = CH¿2?, -C CH, straight or branched C1-C6-alkyl, C3-C7-cycloalkyl, phenyl or optionally substituted phenyl; may be used for the preparation of a medicament for the treatment of asthma, a medicament for the treatment of blood clots (thrombosis), a medicament being effective against impotence and a medicament being effective against pre-eclampsia.</p> |
