N-(3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydro-naphthalene-2-carboxamide derivatives their preparation and their therapeutic use

摘要

5,6,7,8-tetrahydronaphthalene -2-carboxamide derivs. of formula (I) and their optical isomers and acid-addn. salts are new. R1 = H, halogen, Me or 1-4C alkoxy; R' = H or halogen; R'' = H or OMe; R3 = 1-3C alkyl; R4 = 2,3-dihydro-1H-inden-2-yl, 2,3-dihydro-1H-inden-1-yl or 1,2,3,4-tetrahydronaphthalen-1-yl; or NR3R4 = 1,2,3,4-tetrahydro- 2-isoquinolinyl, 6,7-dimethoxy-1,2,3,4- tetrahydro-2-isoquinolinyl, 5,8-dimethoxy-1,2,3,4- tetrahydro-2-isoquinolinyl, 1,2,3,4-tetrahydro- 9H-pyrido(3,4-b)indol-2-yl, 1,2,3,4-tetrahydro- 9H-pyrido(4,3-b)indol-3-yl, 4,5,6,7-tetrahydro- thieno(2,3-c)pyridin-6-yl, 2,3-dihydro-1H-isoindol-2-yl or 2,3,4,5-tetrahydro-1H -3-benzazepin-3-yl; provided that NR3R4 is not an opt. substd. 1,2,3,4-tetrahydro- 2-isoquinolinyl gp. when R1 = alkoxy and R' = R'' = H.