| 摘要 |
Compounds of general formula (1) are described, wherein = W- is (1) =C(Y)- where Y is a halogen atom, or an alkyl or -XR<a> group where X is -O-, -S(O)m- [where m is zero or an integer of value 1 or 2], or -N(R<b>)- [where R<b> is a hydrogen atom or an optionally substituted alkyl group] and R<a> is a hydrogen atom or an optionally substituted alkyl group or, (2) =N-; L is a -XR, [where R is and optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group], -C(R<11>)=C(R<1>)(R<2>) or or [-CH(R<11>)]nCH(R<1>)(R<2>) group where R<11> is a hydrogen or a fluorine atom or a methyl group, and R<1> and R<2>, which may be the same or different, is each a hydrogen or fluorine atom or an optionally substituted alkyl, alkenyl, alkynyl, alkoxy, alkylthio, -CO2R<8>, [where R<8> is a hydrogen atom or an optionally substituted alkyl, aralkyl, or aryl group], -CONR<9>R<10> [where R<9> and R<10>, which may be the same or different are as defined for R<8>], -CSNR<9>R<10>, -CN or -NO2 group, or R<1> and R<2> together with the C atom to which they are attached are linked to form an optionally substituted cycloalkyl or cycloalkenyl group and n is zero or the integer 1; Z is a group (A), or (B) wherein R<3> is a hydrogen or a fluorine atom, an optionally substituted straight or branched alkyl group, or a hydroxyl group; R<4> is a hydrogen atom or group -(CH2)tAr or -(CH2)t-Ar-(L<1>)n-Ar'; R<5> is a -(CH2)tAr' or -(CH2)t-Ar-(L<1>)n-Ar' group; R<6> is a hydrogen or a fluorine atom, or an optionally substituted alkyl group; R<7> is a hydrogen or a fluorine atom, an optionally substituted straight or branched alkyl group or an OR<c> group where R<c> is hydrogen atom or an optionally substituted alkyl or alkenyl group, alkoxyalkyl, alkanoyl, formyl, carboxamido or thiocarboxamido group; and the salts, solvates, hydrates, prodrugs and N-oxides thereof. Compounds according to the invention are phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of desease such as asthma where an unwanted inflammatory response or muscular spasm is present.
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