Dermatophagoidesista (huonepölypunkeista) peräisin olevien pääasiallisten allergeenien T-soluepitoopit

摘要

The present invention provides isolated peptides and/or modified peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to peptides which have been further modified having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic composition comprising one or more peptides of the invention are also provided.