| 摘要 |
Alpha-substd. arginine aldehyde tripeptide derivs. of formula (I) and their salts and solvates are new. X=aralkanoyl or heterocyclic acyl gp. of formula (X1-X7); Q=OH, 1-4C alkoxy or -NH-A; A=H, 1-4C alkyl, acetyl, CF3CO-, CF3CF2CO-, R''SO2-, benzyloxycarbonyl or tert. butoxycarbonyl; R'=H, 1-4C alkyl, phenyl or benzyl; R''=1-4C alkyl, -(CH2)d-COOH, opt. substd. phenyl, opt. substd. naphthyl or opt. substd. Het; Het=5- or 6-membered heteroaryl or 9- or 10-membered fused bicyclic heteroaryl, both contg. 1 or 2 of S, O and N as heteroatom(s); d=1-3; m,n=0-2; Y=2-carbonyl-pyrrolidino of formula (Y1) or 2- carbonyl-azetidino of formula (Y2); R=Me or Et; Z=H, 1-4C alkyl, 1-4C alkoxy, OH, halo or RaSO2NH-; Ra=1-4C alkyl. |
